We think you have liked this presentation.If you wish to download it, please recommend it to your friends in any social system.Share buttons are a little bit lower.LMMSWe're excited to announce LMMS 1.2.0-RC3!This is the third release candidate for the next stable release and comes with many bug fixes.Users on previous release candidates are strongly recommended to upgrade.// /lmmsio/sets/the-best-of-lmms-vol-4Alle anzeigenLMMSBest of LMMS Volume 4 is just around the corner!We are now collecting the lossless sound files from the artists and will release the album on Bandcamp very soon./lmmsio/sets/the-best-of-lmms-vol-4 Many thanks to everyone who participated and congratulations to the winners!LMMSThe results for Best of LMMS v4 are in!/…/1iJlcktytPyXX637NvSh-gCcmcx…/edit… Congratulations to all the winners!2017 BoL4 Judging Round 2LMMSReminder!!Submit your track here: https://goo.gl/forms/cifEliOViOXTSc8H2LMMSHappy April Fools!Thanks to LocoMatt for the wonderful video.Original description: Be the part of our next journey.

Coming in 3017.Gepostet von LMMSBest of LMMS Volume 4 has started!https://lmms.io/competitions/ We accept submissions hosted on YouTube, Soundcloud and Clyp.Please read the full rules before submitting.Best of LMMS - Volume 4Official Submission form for BoL v4.https://lmms.io/competitions/ Submissions so far: https://goo.gl/kMIYKg Rules: 1.The Deadline: Tracks must be submitted by April 16th at 0:00 UTC using this form.The Tracks: - Must be produced in LMMS.- You may use other programs for mastering and post proc...Mehr dazuLMMSCongratulations to Jousboxx, the Kicker Competition winner.Jousboxx has been awarded an official kicker tshirt!/jousboxx/buzzer-beater Note, this track was composed using ONLY the LMMS Kicker Instrument.LMMSHey guys, we have a neat challenge for you.We're hosting a Kicker challenge!1) The only permitted instrument is Kicker.No samples, no other synths, etc. 2) External VST FX plugins are allowed.3) Your track must be at least 1 minute long.4) No remixes are allowed.

The winner will get a kicker branded t-shirt.Head over to the discord server at https://discord.gg/H4gvR6A to check it out.Deadline is March 5th, 2017.DiscordLMMSWe are proud to present you with a new RC for LMMS 1.2.It includes the brand new, completely redesigned look of LMMS, the ability to play sample tracks from any point in the song (does not work with tempo automation) and many other enhancements.möbel in holland kaufen zoll/LMMS/lmms/releases/tag/v1.2.0-rc2 Download here: https://lmms.io/download Please note that this is a pre-release meant for testing and can contain bugs.gartenmöbel rattan günstig ottoIf you run into any issues let us know!LMMS • DownloadLMMS hat sein/ihr Titelbild aktualisiert.LMMS 1.2.möbellagerung berlin preise

We are proud to announce the results of this year's Best of LMMS contest.Thanks to everyone who participated, and congratulations to the winners!We are gathering the lossless sound files from the winners, and will announce the release date soon.möbelhäuser einrichtungshäuser magdeburg/lmmsio/sets/the-best-of-lmms-vol-3 Winners, ranked by score: 1.möbelhäuser um weidenStakeout Punch – Desolate 2.gebrauchte möbel augsburg oberhausenKWAK & LocoMatt – $wagBoy 3.Sti-Jay – Summer Party 4. hai – Superfont 5.Fastigium – City At Night 6.T0NIT0 RMX – Beyond The Limits 7.Histakes – Nebulae 8. caLRo – Warm Glow 9.Hashhakaj Kamaluden – Mystery Of The Blues SF 10.Milymus – Waltz of Crisis 11.WaterNode – A Rainy Night At The Pub 12.

Ckrown – The Origins 13. jaehl – Caribbean Flavor 14.NoiseTacticz – Musical Mastermind 15.Jacoby Davis – Lux 16.Jernemies – I began from a village theme 17.Strigen – Appeal To Reason 18. gdd7171 – Space Rain 19.Cubiicle – Through The Stars 20.MSL – Jukeboxer 21.Simone Iervasi – KRAKEN 22.Lockdown_Music – Nightmares About Ghosts 23. xrri – Odyssey 24.GoAm – Second Try 25.Arsanthania – Desolate Station Honourable mentions: 26.9CaptainCow9 – 12:34 27.Nesdood007 – The Apocalypse 28.Deeptone Overdose – Darkness 29.Joshua Johnson – Exquisite Chrysalis 30.RetroCompute – Midnight Ride 31.Camerican – Crown Vic The best of LMMS vol.3Thanks to everyone who participated, and congratulations to the winners!/ /groups/the-best-of-lmms-competition-LMMSWe received a word from Bandcamp: we can't actually upload a 161 track album, so the judges will still need to do their work.On a more serious note, we were seriously overwhelmed with the number of submissions this year, but don't worry, our judges are working around the clock to finish up the judging, and present you with the winners as soon as possible.LMMSDue to the amazing submissions we received for Best of LMMS vol.3, we want to announce that we couldn't pick a winner.

So, we decided that you are all winners.Everyone gets first place!To celebrate that, we give each of the 161 submitters a medal!Congratulations!LMMS24 Hours left to submit your song!Share Published on Nov 6, 2014 This paper is based on the importance of phytochemicals in our health.How this nutrients from plants help us combat series of degenerative diseases and mechanism of actions.... Health & Medicine 0 Comments Statistics Notes Show More Views Actions 0 Embeds 0 1.1 INTRODUCTION 1.1 Definition Flavonoids are low molecular weight (Fernandez et al., 2006) bioactive polyphenols which play a vital role in photosynthesising cells (Tim-Cushnie and Andrew, 2005).They are also referred to as “Phytochemicals” which are substances found in edible fruits and vegetables that exhibit a potential for modulating human metabolism in a manner beneficial for the pre-vention of chronic and degenerative diseases (Tripoli et al., 2007).

1.2 Description Like other phytochemicals, they are the products of secondary metabolism of plants and cur-rently, it is not possible to determine precisely their number, though over 4000 have been identified.Flavonoids are ubiquitous in photosynthesising cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey (Tim-Cushnie and Andrew, 2005).Flavonoids esterified with sulfate groups have been reported to occur in many plant species, in particular mono- to tetrasulfate esters of flavonols and flavones, and their methylated or glycosylated derivatives (Andersen et al., 2006).The dietary intake of flavonoids is estimated to be 1- 2g/day (Fernandez et al., 2006).They have been found to possess various effects: both beneficial and harmful.Nowadays many pharmaceuticals con-tain flavonoids as active substance (Marzena and Mateusz, 2012).For example quercetin, the most biologically active and popular dietary flavonoid, is generally used as a dietary supple-ment (Torreggiani et al., 2005).

Flavonoids have free radical scavenging and antioxidation properties, which are useful for their pharmacological activities including their anticancer and anti-ageing properties (Sharma, 2006).2 BIOCHEMISTRY OF FLAVONOIDS 2.1 Nomenclature and Characterisation of flavonoids The basic structure of flavonoids is the flavylium cation (Marzena and Mateusz, 2012) or 2-phenyl-benzo-γ-pyrane (Bimlesh et al., 2011).Two benzene rings A and B linked by a three carbon chain that forms a closed pyran ring (heterocyclic ring containing oxygen, the C ring) with benzenic A ring.Figure 1: Flavonoid skeleton (Bimlesh et al., 2011) Flavonoids differ in their arrangement of hydroxyl, methoxy and glycosidic side groups and in the conjunction between A and B rings (Heim et al., 2002).A variation in C ring provides division of subclasses (Tsuchiya, 2010).Flavonoids are divided into eight different groups: flavonols, flavanones, flavones, isoflavones, catechins, anthocyanidins, dihydroflavonols and chalcones (Lu et al., 2006).

3 Table 1: Classification of some flavonoids and their common sources (Mukesh et al., 2005) Chemical Class Example Major Dietary Source Flavonol Quercetin, Rutin, Myrice-tin, Kaempferol Tea, Red wine, Apple, To-mato, Cherry and Onion Flavanols Catechin, Gallocatechin Tea and Apple Flavones Apigenin, Luteolin, Chrysin Thyme and Parsley Isoflavones Genistein, Glycitein, For-mononetin, Daidzein Soya bean and other leg-umes Flavanones Hesperidin, Narigenin Grape fruit and Orange Flavanonols Taxifolin Lemon and sour orange Figure 2: Chemical structure of some representative flavonoids (Tapas et al., 2008) 4.In plants, flavonoids are often present as O-glycosides or C-glycosides (Bimlesh et al., 2011).The O-glycosides possess sugar substituent bound to –OH of aglycone, usually at position 3 or 7, whereas, C-glycosides possess sugar groups bound to Carbon of aglycone usually 6-C or 4 8-C (Rijke et al., 2006).

2.2 Bioavailability and Metabolism of Flavonoids According to U.S.Food and Drug Administration (FDA), the definition of bioavailability is “the rate and extent to which the active ingredient or active moiety is absorbed from a drug product and becomes available at the site of action.Despite the health claim of flavonoids, its bioavailability is generally low and can vary drastically among different flavonoid classes as well as individual compounds in a particular class (Surangi et al., 2013).Relative urinary ex-cretion of anthocyanins and diadzein according to Landete (2012) intake was 0.3% and 43% respectively which explains the variability of bioavailability of flavonoids.When it comes to flavonoids with complex structures and larger molecular weights, bioavailability may be even lower (Landete, 2012).It is quite well established that once eaten, polyphenols enter a complex pathway of bio-transformation so that, the molecular forms reaching the peripheral circulation and tissues to be excreted are usually different from those present in foods (Manach et al., 2004).

Flavo-noids are substrates for conjugating and hydrolyzing enzymes in the small intestine, liver and colon and all are conjugated to O-glucuronides, sulfate esters and O-methyl esters and hardly any aglycones are present in the plasma (Landete, 2012).5 Ingested flavonoids Glycosides LPH hydrolysis Aglycones Phase I & II metabolism Target cells and tissues Blood Methyl Sulphate Glucoronic acid Hepatic Portal Vein Metabolites Phase I & II metabolism Metabolites (sulphates, glucoronides and/ or methylates) Liver Intestinal re-absorption Flavonoids Phenolic acids Bile Blood COLON Excretion via urine Fecal Elimination Figure 3: A Schematic of Human Flavonoid Metabolism (Surangi et al., 2013).6 ROLES OF FLAVONOIDS IN CHRONIC DISEASES Epidemiological studies have supported the association between better health and long-term consumption of diets rich in foods of plant origin (Jansen et al., 2004).

However, this is so because such diets minimize exposure to deleterious substances (e.g., oxidized cholesterol, pyrolysis mutagens, salt, saturated fat, etc.), or maximize intake of certain beneficial nutrients (e.g., isothiocyanates and other sulfur-containing plant constituents, mono-unsaturated fatty acids, and poly-unsaturated fatty acids, PPT, polyacetylenes, selenium, terpenes, etc.)or some combination as advocated in the ‘‘Polymeal’’ concept, remains unknown (Franco et al., 2004).3.1 Antioxidant Activity of Flavonoids Oxidation is the transfer of electrons from one atom to another (Yaseen et al., 2010).Prob-lems may arise however when the electron flow generates free radicals, such as O2-centred free radicals, known as reactive oxygen species (ROS), and including superoxide (O2˙¯), per-oxyl (ROO˙), alkoxyl (RO˙), hydroxyl (HO˙) and nitric oxide (NO˙) radicals (Hamdoon, 2009).This oxidative damage is considered to play a causative role in ageing and several de-generative diseases associated with it, such as heart disease, congestive dysfunction and can-cer (Mohammad et al., 2011).

To protect the body from such effects; in addition to antioxi-dant enzymatic system, there are non-enzymatic biomolecules and proteins in living organ-isms, which act as antioxidant and free radical scavengers (Khan et al., 2012).However, food supplementation containing ascorbates, carotenoids, tocopherols, flavonoids and phenols play a significant role in this matter (Patricia, 2005).Indeed, the phenolic groups of flavonoids serve as a source of a readily available ‘‘H” atoms such that the subsequent radicals produced can be delocalized over the flavonoid structure (Tripoli et al., 2007).Flavonoids inhibit lipid peroxidation in vitro at an early stage by acting as scavengers of superoxide anion and hy- 7. droxyl radicals (Bimlesh et al., 2011).They terminate chain radical reaction by donating hy-drogen atom to a peroxy radical as in the figure below, thus, forming flavonoids radical, which, further reacts with free radicals thus terminating propagating chain (Ferreira et al., 7 2010).

Figure 4: Formation of peroxy radical (Bimlesh et al., 2011) 3.2 Cardio protective Effect of Flavonoids Compiled data from several epidemiological studies about cardio protective effect of flavo-noids strengthens the inverse association between dietary flavonoid intake and incidence of coronary heart diseases (Maron, 2004).In the context of vascular disease, numerous studies have focused on the ability of phenolic compounds, as pure aglycones and as glycosides, to delay the oxidation of LDL in vitro (Kahkonen and Heinonen, 2005).Reactive Oxygen Spe-cies induced oxidative stress, a pathological determinant, is involved in the development and progression of various cardiovascular diseases (Becker, 2004).Previous studies have demon-strated that ROS generated intracellularly causes membrane lipid peroxidation and oxidative damage to nucleic acids, carbohydrates, and proteins, potentially leading to myocardial cell damage and death (Bergamini et al., 2004).

As evidenced, free radical scavenging and antiox-idant activities of flavonoids may thus be correlated with their cardio protective effects (Mukesh et al., 2005).Flavonoids have been suggested to reduce the risk of cardiovascular disease by modulating various mechanisms (Schroeter et al., 2010).However, the association between cancer risk and dietary flavonoid intake has less supportive evidence from epidemio-logical studies, and the results have been inconsistent (Woo and Kim, 2013).To date, meta- 8. analyses have focused mainly on dietary flavonoids and cardiovascular disease (Hooper et 1 Artherosclerosis Decrease in LDL oxidation by LOX inhibition and attenuation of oxidative stress, inhibition of leucocyte leucocyte adhesion, myeloperoxidase, decreased expression of iNOS and COX-2.4 Heart Failure Decrease in oxidative stress (direct ROS scavenging) inhibi-tion 5 Hypertension Vasodilatory properties, inhibition of NADPH oxidase, recov-ery 8 al., 2008) or tea flavonoids and lung cancer (Sun et al., 2006).

Table 2: Proposed positive effect of flavonoids on cardiovascular diseases (Bimlesh et al., 2011) S/N Cardiovascular diseases Influence of Flavonoids 2 Arrhythmia Decrease in oxidative stress.3 Acute Myocardial infarc-tion Decrease in ROS burst, inhibition of platelet aggregation of metalloproteinase of NO due to inhibition of superoxide production 3.3 Anti-Carcinogenic Effect of Flavonoids Stomach and colorectal cancer are common cancers and leading causes of cancer deaths (Ferley et al., 2010).Flavonoids are a large and diverse group of phytochemicals and re-search into their anti-carcinogenic potential with animal and cellular model systems supports a protective role (Nichenametla et al., 2006).Dietary flavonoids inhibit the proliferation of various cancer cells and tumour growth in animal models (Kanadaswami et al., 2005).Flavo- 9. noids are potent bioactive molecules that possess anticarcinogenic effects since they can in-terfere with the initiation, development and progression of cancer by the modulation of cellu-lar proliferation, differentiation, apoptosis, angiogenesis and metastasis (Ramos, 2007) as 9 shown in the figure below: Figure 5: Multistage of Carcinogenesis and potential effects of polyphenols on cancer pro-gression (Ramos, 2007) Epidemiologic data suggested that flavonoids consumption may protect against cancer induc-tion in several human tissues (Ewelina et al., 2008).

Chemoprevention has the potential to be a major component of colon, lung, prostate and bladder cancer control (Thomasset, 2007).Recently it has been reported that flavonoids sensitized in vitro cancer cells to apoptosis in-duced by anticancer agents, for example the tumour necrosis factor (TNF) (Nozawa et al., 2004).3.4 Anti-Inflammatory effect of Flavonoids In inflammation, bacterial products and proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and com-pounds that inhibit NO production have anti-inflammatory effects (Mari et al., 2007).A main function of inflammation is to resolve infection and to repair the damage in order to achieve homeostasis equilibrium (Garcı´a-Lafuente et al., 2009).Thus, the ideal inflammatory re-sponse is rapid and destructive, yet specific and self-limiting (Barton, 2008).Although ste-roidal anti-inflammatory drugs and NSAIDs are currently used to treat acute inflammation, 10. these drugs have not been entirely successful in curing chronic inflammatory disorders while such compounds are accompanied by unexpected side effects (Garcı´a-Lafuente et al., 2009).

Therefore, there is an urgent need to find safer anti-inflammatory compounds (Yoon and 10 Baek, 2005).It has been reported that flavonoids are able to inhibit expression of isoforms of inducible ni-tric oxide synthase, cyclooxygenase, and lipooxygenase, which are responsible for the pro-duction of a great amount of nitric oxide, prostanoids, leukotrienes, and other mediators of the inflammatory process such as cytokines, chemokines, or adhesion molecules.Apigenin, luteolin, quercetin are known to possess anti-inflammatory activity (Tapas et al., 2008).Kaempferol, quercetin, myricetin, fisetin are reported to possess COX and LOX inhibitory activities (Tapas et al., 2008).Flavonoids also inhibit cytosolic and tyrosine kinase (Kang et al., 2009) and also inhibit neutrophil degranulation.Figure 6: Effect of Flavonoids on inflammation (Bimlesh et al., 2011) 11.11 OTHER EFFECTS OF FLAVONOIDS 4.1 Gastro-protective Activity of Flavonoid Peptic ulcer is a gastro intestinal disorder due to an imbalance between the aggressive factors like acid, pepsin, Helicobacter pylori and defensive factors like bicarbonate secretion, prosta-glandins, gastric mucus, innate resistance of the mucosal cell factors (Dashputre et al., 2011).

The mechanism of action responsible for the anti-ulcer activity of flavonoids is their antioxi-dant properties, seen in garcinol, rutin and quercetin, which involve free radical scavenging, transition metal ions chelation, inhibition of oxidizing enzymes, increase of proteic and nonproteic antioxidants and reduction of lipid peroxidation (Mohamed and Azza, 2011).4.2 Antimicrobial Activity of Flavonoids 4.2.1 Antifungal Activity Humans and fungi share some of the same molecular processes; therefore, there is always the risk that what is toxic to the fungal cells will be toxic to the host cells (Tasleem et al., 2009).The drugs that were used to treat fungal infections have recoiled because fungi have devel-oped resistance and also some adverse effects.It is then necessary to find alternative means to combat these fungal infections.Amentoflavone from Selaginella tamariscina exhibited po-tent antifungal activity (IC50 value of 18.3 mg/ml) against several pathogenic fungal strains and has a very low haemolytic effect on human erythrocytes (Jung et al., 2006).

An isoflavan, 2-hydroxy maackiain from the root extract of Hildegar diabarteri was observed to have antifungal activity (Meragelman et al., 2005).Flavonoid derivatives, scandenone, tiliroside, quercetin-3,7-O-α-Ldirhamnoside, and kaempferol-3,7- O-α-L-dirhamnoside, were reported to have antifungal activities against C. albicans at 1.0mg/ml as potent as ketocona-zole (Ozҫelik et al., 2006).4.2.2 Antibacterial Activity 12.A number of flavonoids have displayed antibacterial activities.Rattanachaikunsopon et al., (2010) isolated morin-3-O-lyxoside, morin-3-O-arabinoside, quercetin, quercetin-3-O-arabinoside from Psidium guajava leaves and reported that these four possess bacteriostatic action action against all foodborne pathogenic bacteria including Bacillus stearothermophi-lus, Brochothrix thermosphacta, Escherichia coli, Listeria monocytogenes, Pseudomonas flu-orescens, Salmonella enteric, Staphyloccus aureus, Vibrio cholera.Flavonones having sugar moiety showed antimicrobial activity while none of the flavonols and flavonolignans showed inhibitory activity on microorganisms (Bimlesh et al., 2011).

Quercetin has been reported to 12 completely inhibit growth of Staphylococcus aureus (Tapas et al., 2008).4.2.3 Antiviral Activity The mechanism of antiviral action of polyphenolic compounds is based on their abilities to act as antioxidants, inhibit enzymes, disrupt cell membranes, prevent viral binding and pene-tration into cells, and trigger the host cell self-defense mechanisms (Mendel, 2007).A recent area of research that is of particular interest is the apparent inhibitory activity of some flavo-noids against human immunodeficiency virus (HIV) (Tim-Cushnie and Andrew, 2005).HIV- 1 infection of the host cells proceeds with reverse transcription, viral DNA integration into the host genome, transcription, translation, proteolytic processing of viral proteins and subse-quent assembly into nascent viral particles (Greene and Peterlin, 2002).Luteolin, quercetin, myrecetin have been found to have anti-HIV-1 activity (Tewtrakul et al., 2003).

In an exper-iment carried out by Mehla et al., (2011), Luteolin was the most potent and inhibited HIV-1 infection by abrogating Tat-mediated LTR activity.4.3 Hepatoprotective Activity of Flavonoids Different chronic diseases such as diabetes may lead to development of hepatic clinical mani-festations.glutamate-cysteine ligase catalytic subunit (Gclc) expression, glutathione, and ROS levels are reported to be decreased in liver of diabetic mice (Shashank and Abhay, 13.demonstrated that anthocyanin cyanidin-3-O-β-glucoside (C3G) increases hepatic Gclc expression by increasing cAMP levels to activate protein kinase A (PKA), which in turn upregulates cAMP response element binding protein (CREB) phosphorylation to promote CREB-DNA binding and increase Gclc transcription.Increased Gclc expression 13 results in a decrease in hepatic ROS levels and proapoptotic signaling (Zhu et al., 2012).Silymarin has been reported to stimulate enzymatic activity of DNA-dependent RNA poly-merase 1 and subsequent biosynthesis of RNA and protein, resulting in DNA biosynthesis and cell proliferation leading to liver regeneration only in damaged livers ((Bimlesh et al., 2011).

Silymarin has clinical applications in the treatment of cirrhosis, ischemic injury, and toxic hepatitis induced by various toxins such as acetaminophen, and toxic mushroom (Saller et al., 2011).Anti-thrombotic Activity of Flavonoids Arachidonic acid released by in inflammatory conditions is metabolized by platelets to form prostaglandin, endoperperoxides and thromboxane A2 thus contributing to platelet activation and aggregation (Bimlesh et al., 2011).Platelet aggregation further contributes to atheroscle-rosis and acute platelet thrombus formation.According to Bimlesh et al., flavonoids are used as antithrombotic due to their ability to scavenge free radicals.The main antiaggregatory ef-fect is by the inhibition of thromboxane A2 formation.Flavonoids like quercetin, kaempferol and myricetin are known to possess antiaggregatory properties (Tapas et al., 2008).FLAVONOID TOXICITY PROFILE 14.It has been suggested that because flavonoids are widely distributed in edible plants and bev-erages and have previously been used in traditional medicine, they are likely to have minimal toxicity (Tim-Cushnie and Andrew, 2005).

Given that the selectivity of flavonoids for eukar-yotic enzymes appears to vary from compound to compound, a study regarding assessment of its toxicity is required to be done on these phytochemicals on an individual basis (Tim- 14 Cushnie and Andrew, 2005).High doses do not appear to cause serious side effects, even for amounts as high as 100 grams a day.Excess intake is simply excreted in urine.As for green tea, highly concentrated doses of it might contain too much caffeine for cancer and hepatitis patients, and for those people sensitive to caffeine (HSNG, 2008).Several diseases have found their way to exist among humans.These diseases are caused by microorganisms, most of which have made the internal environment of human (Host) their abode.Many drugs are used to combat these diseases, but because of the various side effects and even the ability of these organisms to develop resistance, the efficacy of these drugs has decreased over the years.

Researchers have therefore resorted to the ancient means of treating 15 diseases i.e.the use of natural medicinal plants.Dietary flavonoids found in vegetables, fruits, chocolates e.t.c.are hereby recommended to be part of our daily diet since studies have demonstrated positive effects in the prevention and treatment of many diseases.However, further research is needed to affirm the dosage limits of these bioactive compounds and also discover more.M., and Kenneth R.M.Molecular Biology and Biotechnology of Flavonoid Biosynthesis.FLAVONOIDS-Chemistry, Biochemistry and Applications, Taylor & Fran-cis, 16 New-York.A calculated response: control of inflammation by the innate immune system.Journal of Clinical Investigation, 118:413–420.New concepts in Reactive oxygen species and cardiovascular reperfusion physiology.Cardiovascular Rescue, 61(3): 461- 470.Bergermini, C.M., Gambetti, S., Dondi, A., and Cervellati, C. (2004).Oxygen, Reactive Oxygen Species and tissue damage.

Current Pharmaceutical Design, 10(14): 1611- 1626.Bimlesh, K., Sunil, P., Manoj, S., Pardeep S., and Harleen S.A Review of Phytochemis-try and pharmacology of Flavonoids.Internationale Pharmaceutica Scientia, 1 (1): 25- 38.Dashputre N.L., and Naikwade N.S.Evaluation of Anti-Ulcer Activity of Methanolic Extract of Abutilon indicum Linn Leaves in Experimental Rats.International Journal of Pharmaceutical Sciences and Drug Research, 3(2):97- 100.De Campos M.P., V. Chechinel Filho, R.Z., Da Silva, R.A., Yunes, S. Zacchino, S. Juarez, R.C.Bella Cruz, and A. Bella Cruz (2005).Biological and Pharmaceutical Bulletin, 28: 1527.Ewelina Szliszka, Zenon P. Czuba, Katarzyna Jernas and Wojciech Król (2008).Dietary Flavo-noids Sensitize HeLa Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL).International Journal of Molecular Science, 9: 56- 64.Ferley, J., Shin, R., Bray, F., Forman, D., Mathers, C., and Parkin, D.Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.

International Journal of Can-cer, 17 127: 2893- 2917.Fernandez, S., Wasowski, C., Loscalzo, M., Granger, E., Johnston, A., Paladini, C., and Marder, M. (2006).Central nervous system depressant action of flavonoid glycosides.European Journal of Pharmacology; 539: 168-176.Ferreira, J., Luthria, D., Sasaki, T., Heyerick, A.Flavonoids from Artemisia annuaas antioxidants and their potential synergism with Artemisinin against malaria and cancer.Franco, O., Bonneux, L., Peeters, A., and Steyerberg, E.W.The Polymeal: a more natural,safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.British Medical Journal, 329: 18 Fresco, P., Borges, F., Diniz, C., and Marques, M. (2006).New insights on the anticancer proper-ties of dietary poliphenols.Medicinal Research Reviews, 26: 747 – 766.Garcı´a-Lafuente A., Guillamόn, E., Villares, A., Rostagno, A., and Martinez, A.Flavo-noids as anti-inflammatory agent: implications in cancer and cardiovascular diseases.

In-flammation Research, 58: 537- 544.Greene, W.C., and Peterlin, B.Charting HIV's remarkable voyage through the cell.Basic science as a passport to future therapy.Nature Medicine, 8: 673–680.Natural and synthetic flavonoid derivatives with potential Antioxidant and Anticancer Activities.Health Supplement Nutritional Guide (2008).VITAMIN P. Retrieved 2nd October, 2014.Heim, K.E., Tagliaferro, A.R., Bobliya, D.J.Flavonoids antioxidants: Chemistry, metab-olism and structure-activity relationships.The Journal of Nutritional Biochemistry, 18 13:572-584.Hooper, L., Kroon, P., Rimm, E., Cohn, J., Harvey, I., Hall, W., Ryder, J., Le Cornu, K., and Cassidy A.Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials.American Jounal of Clinical Nutrition, 88: 38- 50.Jansen, M.C., McKenna, D., Bueno-de-Mesquita, H.B., Feskens, E.J., Streppel, M.T., Kok, F.J., and Kromhout, D.Reports: quantity and variety of fruit and vegetable consump-tion and cancer risk, Nutrition and Cancer, 48:142.

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